Efficacy and safety of medical ozone (O3) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: Preliminary results of a phase I–II study
نویسندگان
چکیده
1368-8375/$ see front matter 2011 Elsevier Ltd. A doi:10.1016/j.oraloncology.2011.01.002 q The procedures followed in this study were rev Ethics Committee of National Cancer Institute of Mila the ethical standards of the Helsinki Declaration (19 1989, 1996 and 2000) of the World Medical Associati ⇑ Corresponding author. Address: Supportive Care dation, National Cancer Institute of Milan, Via Venezia +39 02 23903644; fax: +39 02 23904847. E-mail address: [email protected]
منابع مشابه
Efficacy and tolerability of medical ozone gas insufflations in patients with osteonecrosis of the jaw treated with bisphosphonates—Preliminary data☆
Osteonecrosis of the Jaw (ONJ) is an adverse event reported especially in patients receiving cancer treatments regimen, bisphosphonates (BPs), and denosumab. We performed an open-label, prospective study in patients treated with zoledronic acid who developed ONJ lesions 42.5 cm, and had no benefit after the treatment with the standard therapy, to evaluate the efficacy and tolerability of medica...
متن کاملTreatment of osteonecrosis of the jaw (ONJ) by medical ozone gas insufflation. A case report.
Osteonecrosis of the jaw (ONJ) is an adverse event reported in patients receiving cancer treatment, especially bisphosphonates and denosumab. A patient with multiple myeloma who underwent up to 22 intravenous zoledronic acid infusions without previous dental examination developed a devastating ONJ lesion in the right horizontal mandibular ramus. He was treated with local ozone gas applications ...
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